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Article

The interplay between binding energy and catalysis in the evolution of a catalytic antibody.

Nature - 18 Sept 1997

Ulrich H D, Mundorff E, Santarsiero B D, Driggers E M, Stevens R C, Schultz P G

Abstract excerpt

Antibody catalysis provides an opportunity to examine the evolution of binding energy and its relation to catalytic function in a system that has many parallels with natural enzymes. Here we report such a study involving an antibody AZ-28 that catalyses an oxy-Cope rearrangement, a pericyclic reaction that belongs to a well studied and widely used class of reactions in organic chemistry. Immunization with...

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Identifiers

PMID: 9305839
DOI: 10.1038/38470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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