Article
Immune recognition, antigen design, and catalytic antibody production.
Applied biochemistry and biotechnology - 1 Jan 1994
Tramontano A
Abstract excerpt
Catalytic antibodies have been developed by experimental approaches exploiting the analogy between antibody-antigen and enzyme-substrate interaction. Haptens have been prepared to model the electrostatic or geometric attributes of a reaction's transition state and to induce combining sites having appropriate catalytic residues. The relative merits of these design strategies may be gleaned from the apparent...
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