Article
A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis.
The New England journal of medicine - 25 Apr 1996
Weiss E J, Bray P F, Tayback M, Schulman S P, Kickler T S, Becker L C, Weiss J L, Gerstenblith G, Goldschmidt-Clermont P J
Abstract excerpt
BACKGROUND: Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor, and it has an important role in platelet aggregation. It is known to be involved in the pathogenesis of acute coronary syndromes. Previously, we found a high frequency of a particular polym...
Topics
- Acute Disease
- Angina, Unstable
- Case-Control Studies
- Coronary Thrombosis
- Female
- Genotype
- Humans
- Logistic Models
- Male
- Middle Aged
- Myocardial Infarction
- Platelet Glycoprotein GPIIb-IIIa Complex
- Polymorphism, Genetic
- Risk Factors