Platelet glycoprotein receptor IIIa polymorphism PLA1/PLA2 and coronary risk: a meta-analysis.

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Article

Platelet glycoprotein receptor IIIa polymorphism PLA1/PLA2 and coronary risk: a meta-analysis.

Thrombosis and haemostasis - 1 Apr 2001

Di Castelnuovo A, de Gaetano G, Donati M B, Iacoviello L

Abstract excerpt

Membrane glycoprotein IIb/IIIa plays a major role in platelet function. The gene encoding the glycoprotein IIIa shows a common polymorphism PLA1/PLA2 that was variably associated with vascular disease. To clarify the role of PLA1/PLA2 polymorphism in coronary risk, a meta-analysis of published data was conducted. Studies were identified both by MEDLINE searches, and hand searching of journals and abstract books....

Topics

Adult
Age Factors
Aged
Antigens, Human Platelet
Bias
Chromosomes, Human, Pair 17
Coronary Disease
Epidemiologic Research Design
Female
Gene Frequency
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Integrin beta3

Male

Middle Aged

Myocardial Revascularization

Odds Ratio

Source

Open in PubMed

Identifiers

PMID: 11341496

Genes

Provenance

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