Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Robust tolerance to fully allogeneic islet transplants achieved by chimerism with minimal conditioning.

Transplantation - 15 Aug 2005

Luo Bin, Nanji Sulaiman A, Schur Colleen D, Pawlick Rena L, Anderson Colin C, Shapiro A M James

Abstract excerpt

BACKGROUND: Whether mixed chimeras induced by nonmyeloablative conditioning are tolerant to challenge with donor allogeneic islet grafts is unknown. Here we investigate whether our nonmyeloablative, costimulation blockade-free and sirolimus (SRL)-based protocol could facilitate mixed chimerism via bone marrow transplantation (BMT) and induce islet allograft tolerance. METHODS: After low dose (1-3 Gy) total body...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD40 Ligand
Share to Cyclophosphamide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Experimental

Share to Lymphocyte Culture Test, Mixed

Share to Lymphocyte Depletion

Share to Transplantation Chimera

Share to Transplantation Conditioning

Share to Transplantation Tolerance

Source

Identifiers

PMID: 16082333
DOI: 10.1097/01.tp.0000167724.38038.ae

Genes

SRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Robust tolerance to fully allogeneic islet transplants achieved by chimerism with minimal conditioning.PMID 16082333Read ↗

Establishment of stable multilineage hematopoietic chimerism and donor-specific tolerance without irradiation.Semantic proximity Read ↗

Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice.Semantic proximity Read ↗

Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future PerspectivesSemantic proximity Read ↗

Chimerism and Tolerance Without GVHD or Engraftment Syndrome in HLA-Mismatched Combined Kidney and Hematopoietic Stem Cell TransplantationSemantic proximity Read ↗

Immunosenescence does not abrogate engraftment of murine allogeneic bone marrow.Semantic proximity Read ↗

Mixed allogeneic chimerism and tolerance to composite tissue allograftsSemantic proximity Read ↗

Mixed Chimerism and Transplantation ToleranceSemantic proximity Read ↗

Mixed chimerismSemantic proximity Read ↗

Chimerism-based Tolerance Induction in Clinical Transplantation: Its Foundations and MechanismsSemantic proximity Read ↗

Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies.Semantic proximity Read ↗

Stable Multilineage Chimerism without Graft versus Host Disease Following Nonmyeloablative Haploidentical Hematopoietic Cell TransplantationSemantic proximity Read ↗

A nonlethal conditioning approach to achieve durable multilineage mixed chimerism and tolerance across major, minor, and hematopoietic histocompatibility barriersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.