Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation analysis of the BRCA1 gene in 76 Japanese ovarian cancer patients: four germline mutations, but no evidence of somatic mutation.

Human molecular genetics - 1 Oct 1995

Matsushima M, Kobayashi K, Emi M, Saito H, Saito J, Suzumori K, Nakamura Y

Abstract excerpt

To investigate the putative role of BRCA1, a gene involved in hereditary breast and ovarian cancer, in sporadic ovarian tumors among Japanese women, we examined 76 unselected primary ovarian cancers for mutations in the coding region of BRCA1 using the single-strand conformation polymorphism technique. Although no somatic mutations were detected in any of the tumors, constitutional mutations were identified in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Molecular Sequence Data

Share to Mutation

Share to Point Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 8595420
DOI: 10.1093/hmg/4.10.1953

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation analysis of the BRCA1 gene in 76 Japanese ovarian cancer patients: four germline mutations, but no evidence of somatic mutation.PMID 8595420Read ↗

Mutations in the BRCA1 gene in Japanese breast cancer patients.Semantic proximity Read ↗

Mutational analysis of BRCA1 and BRCA2 and clinicopathologic analysis of ovarian cancer in 82 ovarian cancer families: two common founder mutations of BRCA1 in Japanese population.Semantic proximity Read ↗

Germline mutations of BRCA1 and BRCA2 in Korean sporadic ovarian carcinoma.Semantic proximity Read ↗

High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families.Semantic proximity Read ↗

Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer.Semantic proximity Read ↗

Mutational analysis of TP53 and p21 in familial and sporadic ovarian cancer in Japan.Semantic proximity Read ↗

Study of BRCA1 gene in hereditary breast and ovarian cancer.Semantic proximity Read ↗

Multiplex mutation screening of the BRCA1 gene in 1000 Japanese breast cancers.Semantic proximity Read ↗

Mutation screening of the BRCA1 gene in sporadic breast cancer in southern Chinese populations.Semantic proximity Read ↗

Cross‐sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancerSemantic proximity Read ↗

BRCA1 mutations in familial ovarian cancer.Semantic proximity Read ↗

Somatic mutations in the BRCA1 gene in Chinese women with sporadic breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.