Article
Study of BRCA1 gene in hereditary breast and ovarian cancer.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih - 1 Dec 1999
Xiaoman D, Jinghe L
Abstract excerpt
OBJECTIVE: To investigate the BRCA1 gene in hereditary breast and ovarian cancer, early-onset breast cancer and sporadic ovarian cancer. METHODS: The exons of 2, 11 and 20 of BRCA1 gene were analyzed. Polymerase chain reaction-single strand conformation analysis (PCR-SSCP) and PCR-SSCP combined by restriction enzymes were used to screen for mutations. Mutations were further indentified by sequencing. The loss of...
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