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Article

Multiplex mutation screening of the BRCA1 gene in 1000 Japanese breast cancers.

Japanese journal of cancer research : Gann - 1 Jan 1998

Emi M, Matsushima M, Katagiri T, Yoshimoto M, Kasumi F, Yokota T, Nakata T, Miki Y, Nakamura Y

Abstract excerpt

To detect BRCA1 mutations in Japanese breast cancer patients, we screened 1,000 unselected primary cancers for mutations in exon 11, which accounts for 61% of the entire BRCA1 coding sequence. Using a method based on multiplex single-strand conformational polymorphism (SSCP) analysis of multiple restriction fragments generated by restriction-enzyme digestion of amplified DNA, we identified eight mutations. All...

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Identifiers

PMID: 9510469
DOI: 10.1111/j.1349-7006.1998.tb00472.x
PMCID: PMC5921586

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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