Article
Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint.
The EMBO journal - 1 Sept 1991
Osmani A H, O'Donnell K, Pu R T, Osmani S A
Abstract excerpt
Mutation of nimA reversibly arrests cells in late G2 and nimA overexpression promotes premature mitosis. Here we demonstrate that the product of nimA (designated NIMA) has protein kinase activity that can phosphorylate beta-casein but not histone proteins. NIMA kinase activity is cell cycle regulated being 20-fold higher at mitosis when compared to S-phase arrested cells. NIMA activation is normally required in...
Topics
- Amino Acid Sequence
- Aspergillus nidulans
- Caseins
- Cell Cycle
- Cell Cycle Proteins
- Chromosomes, Fungal
- Electrophoresis, Polyacrylamide Gel
- Enzyme Activation
- Genes, Fungal
- Histones
- Mitosis