A negative regulator of mitosis in Aspergillus is a putative membrane-spanning protein.

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Article

A negative regulator of mitosis in Aspergillus is a putative membrane-spanning protein.

The Journal of biological chemistry - 25 Sept 1990

Engle D B, Osmani S A, Osmani A H, Rosborough S, Xin X N, Morris N R

Abstract excerpt

The temperature-sensitive cell cycle mutation bimE7 of Aspergillus nidulans causes cells to become blocked in mitosis at a restrictive temperature. Previous work has shown that this mitotic block is induced even when cells are arrested in the S or G2 phase. The mitotic block is also observed in cells carrying a null mutation in bimE, obtained by molecular disruption of the gene (Osmani, S.A., Engle, D.B., Doonan,...

Topics

Amino Acid Sequence
Aspergillus
Base Sequence
Blotting, Northern
Blotting, Southern
Cell Cycle
Cell Cycle Proteins
Cloning, Molecular
DNA, Fungal
Fungal Proteins
Genes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Complementation Test

Mitosis

Molecular Sequence Data

Mutation

Phenotype

Plasmids

Poly A

Source

Open in PubMed

Identifiers

PMID: 1697851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1697851-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A negative regulator of mitosis in Aspergillus is a putative membrane-spanning protein.PMID 1697851Read ↗

The Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis.Semantic proximity Read ↗

Mitotic regulation in Aspergillus nidulans.Semantic proximity Read ↗

bimA encodes a member of the tetratricopeptide repeat family of proteins and is required for the completion of mitosis in Aspergillus nidulans.Semantic proximity Read ↗

The bimB3 mutation of Aspergillus nidulans uncouples DNA replication from the completion of mitosis.Semantic proximity Read ↗

Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans.Semantic proximity Read ↗

Mutation in the bimD gene of Aspergillus nidulans confers a conditional mitotic block and sensitivity to DNA damaging agents.Semantic proximity Read ↗

A temperature-sensitive splicing mutation in the bimG gene of Aspergillus produces an N-terminal fragment which interferes with type 1 protein phosphatase function.Semantic proximity Read ↗

Cell cycle regulation by the NEK family of protein kinasesSemantic proximity Read ↗

Evidence for a NIMA-like mitotic pathway in vertebrate cells.Semantic proximity Read ↗

The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.Semantic proximity Read ↗

Dynamic distribution of BIMG(PP1) in living hyphae of Aspergillus indicates a novel role in septum formation.Semantic proximity Read ↗

Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint.Semantic proximity Read ↗

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