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Article

Identification of BIME as a subunit of the anaphase-promoting complex.

Science (New York, N.Y.) - 15 Nov 1996

Peters J M, King R W, Höög C, Kirschner M W

Abstract excerpt

The initiation of anaphase and exit from mitosis require the activation of a proteolytic system that ubiquitinates and degrades cyclin B. The regulated component of this system is a large ubiquitin ligase complex, termed the anaphase-promoting complex (APC) or cyclosome. Purified Xenopus laevis APC was found to be composed of eight major subunits, at least four of which became phosphorylated in mitosis. In...

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Source

Identifiers

PMID: 8895470
DOI: 10.1126/science.274.5290.1199

Genes

APC
CDC16
CDC23
CDC27

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Identification of BIME as a subunit of the anaphase-promoting complex.PMID 8895470Read ↗

Identification of a cullin homology region in a subunit of the anaphase-promoting complex.Semantic proximity Read ↗

Regulation of the anaphase-promoting complex/cyclosome by bimAAPC3 and proteolysis of NIMA.Semantic proximity Read ↗

The Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis.Semantic proximity Read ↗

BIMAAPC3, a component of the Aspergillus anaphase promoting complex/cyclosome, is required for a G2 checkpoint blocking entry into mitosis in the absence of NIMA function.Semantic proximity Read ↗

Mitotic regulation in Aspergillus nidulans.Semantic proximity Read ↗

A negative regulator of mitosis in Aspergillus is a putative membrane-spanning protein.Semantic proximity Read ↗

The anaphase-promoting complex/cyclosome in control of plant development.Semantic proximity Read ↗

Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint.Semantic proximity Read ↗

The destruction box of the cyclin Clb2 binds the anaphase-promoting complex/cyclosome subunit Cdc23.Semantic proximity Read ↗

Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation.Semantic proximity Read ↗

The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.Semantic proximity Read ↗

Dominant alleles of Saccharomyces cerevisiae CDC20 reveal its role in promoting anaphase.Semantic proximity Read ↗

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