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Article

Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2.

Microbiology and immunology - 1 Jan 1995

Suzutani T, Koyano S, Takada M, Yoshida I, Azuma M

Abstract excerpt

The virulence of thymidine kinase-negative herpes simplex virus type 1 (HSV-1; VRTK- strain) and type 2 (HSV-2; UWTK- strain) was studied in comparison with that of their parental strains (VR-3 and UW-268, respectively) in an encephalitis model of adult (4-week-old) and newborn (3-day-old) mice. Viral thymidine kinase (TK) activity was essential for the maximum expression of virulence of HSV-1, because the 50%...

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PMID: 8577269
DOI: 10.1111/j.1348-0421.1995.tb03271.x

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