Article
Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2.
Microbiology and immunology - 1 Jan 1995
Suzutani T, Koyano S, Takada M, Yoshida I, Azuma M
Abstract excerpt
The virulence of thymidine kinase-negative herpes simplex virus type 1 (HSV-1; VRTK- strain) and type 2 (HSV-2; UWTK- strain) was studied in comparison with that of their parental strains (VR-3 and UW-268, respectively) in an encephalitis model of adult (4-week-old) and newborn (3-day-old) mice....
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Brain
- Cells, Cultured
- Herpesvirus 1, Human
- Herpesvirus 2, Human
- Humans
- L Cells
- Mice
- Molecular Sequence Data
- Mutation
- Thymidine Kinase
- Thymidylate Synthase
- Virulence