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Article

Biological properties of herpes simplex virus 2 replication-defective mutant strains in a murine nasal infection model.

Virology - 5 Dec 2000

Jones C A, Taylor T J, Knipe D M

Abstract excerpt

We used a mouse nasal model of herpes simplex virus 2 (HSV-2) infection to examine the biological properties of HSV-2 wild-type (wt), TK-negative, and replication-defective strains in vivo. Nasal septa tissue is the major site of wt viral replication post intranasal (i.n.) inoculation. The HSV-2 strain 186 syn(+)-1 wt virus caused lethal encephalitis at doses of 10(4) PFU and above per nostril, and at lower doses...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11112490
DOI: 10.1006/viro.2000.0628

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Source receipt: pubmed, retrieved 7 Sept 2026.

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