[Attenuation in the virulence of a mutant of Junin virus in suckling mice].

Article

[Attenuation in the virulence of a mutant of Junin virus in suckling mice].

Revista Argentina de microbiologia - 1 Jan 2000

Scolaro L A, Mersich S E, Damonte E B

Abstract excerpt

The virulence in neonatal mice of a temperature-sensitive mutant of Junin virus, named C167, was studied. The thermosensitive properties of this mutant were tested by titration on Vero cells at 37 and 40 degrees C. The ratio of infectivity 40/37 was approximately 100-fold lower for C167 with resp...

Topics

Age Factors
Animals
Antibodies, Viral
Arenaviridae
Arenaviruses, New World
Cricetinae
Hemorrhagic Fever, American
Mice
Mutation
Temperature
Vero Cells
Virus Replication

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