[Temperature sensitive mutant of Herpes simplex virus type 1. I. Pathogenicity and immunogenicity].

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Article

[Temperature sensitive mutant of Herpes simplex virus type 1. I. Pathogenicity and immunogenicity].

Medycyna doswiadczalna i mikrobiologia - 1 Jan 2001

Litwińska B, Trzcińska A, Kańtoch M

Abstract excerpt

The aim of the study was to characterize biological features of the sensitive mutant of HSV-1, derived from McIntyre strain by numerous virus passages at lowered replication temperature (28 degrees C). Pathogenicity of obtained ts mutant for inbred mice lines, CFW/Pzh and BALB/cPzh, was determined. Statistically significant decrease in virulence of the mutant for these mouse lines was demonstrated, as compared...

Topics

Animals
Herpesvirus 1, Human
Methylprednisolone
Methylprednisolone Acetate
Mice
Mice, Inbred BALB C
Mice, Inbred Strains
Mutation
Temperature

Source

Open in PubMed

Identifiers

PMID: 11757407

Provenance

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