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[Temperature sensitive mutant of Herpes simplex virus type 1. I. Pathogenicity and immunogenicity].

Medycyna doswiadczalna i mikrobiologia - 1 Jan 2001

Litwińska B, Trzcińska A, Kańtoch M

Abstract excerpt

The aim of the study was to characterize biological features of the sensitive mutant of HSV-1, derived from McIntyre strain by numerous virus passages at lowered replication temperature (28 degrees C). Pathogenicity of obtained ts mutant for inbred mice lines, CFW/Pzh and BALB/cPzh, was determined. Statistically significant decrease in virulence of the mutant for these mouse lines was demonstrated, as compared...

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PMID: 11757407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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