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Article

Virulence of Herpes Simplex Virus 1 Harboring a UAG Stop Codon between the First and Second Initiation Codon in the Thymidine Kinase Gene.

Japanese journal of infectious diseases - 22 Jul 2022

Nguyen Phu Hoang Anh, Yamada Souichi, Harada Shizuko, Fukushi Shuetsu, Mizuguchi Masashi, Saijo Masayuki

Abstract excerpt

Herpes simplex virus 1 (HSV-1)-TK (8UAG) expresses a truncated thymidine kinase (TK) translated from the second initiation codon due to a stop codon (UAG) at the 8th position (counted from the first initiation codon). Here, we showed that the sensitivity of HSV-1-TK (8UAG) to acyclovir (ACV) is similar to that of the control HSV-1 wild-type (WT), which expresses an intact TK protein. However, HSV-1-TK (44UAG),...

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Identifiers

PMID: 34980708
DOI: 10.7883/yoken.JJID.2021.674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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