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Article

Complementary lethal invasion of the central nervous system by nonneuroinvasive herpes simplex virus types 1 and 2.

Journal of virology - 1 Aug 1991

Nishiyama Y, Kimura H, Daikoku T

Abstract excerpt

It is well-known that viral thymidine kinase (TK) expression is important for the maximum demonstration of virulence of herpes simplex virus (HSV). In this study, we have investigated interactions of a TK- mutant of virulent HSV type 2 (HSV-2) (syn+) and a nonneuroinvasive HSV-1 (syn) in mice. When the mice were inoculated with each virus alone in their rear footpads, no mice were killed even after infection with...

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Identifiers

PMID: 1649347
DOI: 10.1128/JVI.65.8.4520-4524.1991
PMCID: PMC248897

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