Article
Complementary lethal invasion of the central nervous system by nonneuroinvasive herpes simplex virus types 1 and 2.
Journal of virology - 1 Aug 1991
Nishiyama Y, Kimura H, Daikoku T
Abstract excerpt
It is well-known that viral thymidine kinase (TK) expression is important for the maximum demonstration of virulence of herpes simplex virus (HSV). In this study, we have investigated interactions of a TK- mutant of virulent HSV type 2 (HSV-2) (syn+) and a nonneuroinvasive HSV-1 (syn) in mice. Wh...
Topics
- Animals
- Brain
- Central Nervous System
- Central Nervous System Diseases
- Disease Models, Animal
- Foot
- Ganglia, Spinal
- Herpes Simplex
- Kinetics
- Male
- Mice
- Mice, Inbred ICR
- Mutation
- Recombination, Genetic
- Sciatic Nerve
- Simplexvirus
- Spinal Cord
- Thymidine Kinase