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Article

Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits.

Journal of virology - 1 Oct 2001

Perng G C, Esmaili D, Slanina S M, Yukht A, Ghiasi H, Osorio N, Mott K R, Maguen B, Jin L, Nesburn A B, Wechsler S L

Abstract excerpt

Herpes simplex virus type 1 latency-associated transcript (LAT)-null mutants have decreased reactivation but normal virulence in rabbits and mice. We report here on dLAT1.5, a mutant with LAT nucleotides 76 to 1667 deleted. Following ocular infection of rabbits, dLAT1.5 reactivated at a lower rat...

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Topics

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Share to Gene Expression Regulation, Viral
Share to Herpesvirus 1, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11533165
DOI: 10.1128/JVI.75.19.9018-9028.2001
PMCID: PMC114470

Genes

LAT
LAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11533165-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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