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Article

Fine mechanisms of ectromelia virus thymidine kinase-negative mutants avirulence.

Virus research - 1 Oct 1994

Kochneva G V, Urmanov I H, Ryabchikova E I, Streltsov V V, Serpinsky O I

Abstract excerpt

Three independently selected spontaneous thymidine kinase-negative mutants (TK-phenotype) and a recombinant with Escherichia coli beta-galactosidase gene (LacZ+ phenotype) inserted in the viral thymidine kinase gene (tk) were derived from a plaque-cloned isolate of K-1 ectromelia virus strain (TK+ phenotype). Dramatically decreased virulence of TK- variants was observed for all routes of mouse inoculation. The...

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PMID: 7831964
DOI: 10.1016/0168-1702(94)90118-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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