Article
Fine mechanisms of ectromelia virus thymidine kinase-negative mutants avirulence.
Virus research - 1 Oct 1994
Kochneva G V, Urmanov I H, Ryabchikova E I, Streltsov V V, Serpinsky O I
Abstract excerpt
Three independently selected spontaneous thymidine kinase-negative mutants (TK-phenotype) and a recombinant with Escherichia coli beta-galactosidase gene (LacZ+ phenotype) inserted in the viral thymidine kinase gene (tk) were derived from a plaque-cloned isolate of K-1 ectromelia virus strain (TK...
Topics
- Animals
- Brain
- Cell Line
- Chlorocebus aethiops
- Ectromelia virus
- Escherichia coli
- Liver
- Lung
- Male
- Mice
- Organ Specificity
- Phenotype
- Recombinant Fusion Proteins
- Spleen
- Thymidine Kinase
- Viral Proteins
- Virulence
- Virus Cultivation