Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of the virulence of wild-type thymidine kinase (tk)-deficient and tk+ phenotypes of vaccinia virus recombinants after intranasal inoculation of mice.

The Journal of general virology - 1 Jan 1991

Taylor G, Stott E J, Wertz G, Ball A

Abstract excerpt

A recombinant vaccinia virus vector was constructed which expressed the major surface glycoprotein G of human respiratory syncytial virus (RSV) and the thymidine kinase (tk) gene of vaccinia virus. The virulence of this tk+ recombinant virus was compared with that of a tk- recombinant and the wild-type (wt) virus after intranasal inoculation of mice. Respiratory infection with wt virus resulted in a lethal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Viral
Share to Mice
Share to Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Recombination, Genetic

Share to Viral Proteins

Share to Virulence

Share to Virus Replication

Source

Identifiers

PMID: 1990060
DOI: 10.1099/0022-1317-72-1-125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Comparison of the virulence of wild-type thymidine kinase (tk)-deficient and tk+ phenotypes of vaccinia virus recombinants after intranasal inoculation of mice.PMID 1990060Read ↗

Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype.Semantic proximity Read ↗

Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2.Semantic proximity Read ↗

Insertional inactivation of the large subunit of ribonucleotide reductase encoded by vaccinia virus is associated with reduced virulence in vivo.Semantic proximity Read ↗

Pathogenicity of a thymidine kinase-deficient mutant of equine herpesvirus 1 in mice and specific pathogen-free foals.Semantic proximity Read ↗

Recombinant measles viruses with mutations in the C, V, or F gene have altered growth phenotypes in vivo.Semantic proximity Read ↗

Specific phenotypic restoration of an attenuated virus by knockout of a host resistance geneSemantic proximity Read ↗

Deletion of the Herpes simplex 1 internal repeat sequences affects pathogenicity in the mouse.Semantic proximity Read ↗

Complementary lethal invasion of the central nervous system by nonneuroinvasive herpes simplex virus types 1 and 2.Semantic proximity Read ↗

[Attenuation in the virulence of a mutant of Junin virus in suckling mice].Semantic proximity Read ↗

Immediate protection of mice from lethal wild-type Sendai virus (HVJ) infections by a temperature-sensitive mutant, HVJpi, possessing homologous interfering capacity.Semantic proximity Read ↗

Experimental infection of suckling mice with a host range mutant of Junin virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.