Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of the virulence of wild-type thymidine kinase (tk)-deficient and tk+ phenotypes of vaccinia virus recombinants after intranasal inoculation of mice.

The Journal of general virology - 1 Jan 1991

Taylor G, Stott E J, Wertz G, Ball A

Abstract excerpt

A recombinant vaccinia virus vector was constructed which expressed the major surface glycoprotein G of human respiratory syncytial virus (RSV) and the thymidine kinase (tk) gene of vaccinia virus. The virulence of this tk+ recombinant virus was compared with that of a tk- recombinant and the wil...

Topics

Animals
Antigens, Viral
Genes, Viral
HN Protein
Lung
Mice
Mice, Inbred BALB C
Phenotype
Recombination, Genetic
Respiratory Syncytial Viruses
Thymidine Kinase
Vaccinia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vaccinia virus

Viral Envelope Proteins

Viral Proteins

Virulence

Virus Replication

Source

Identifiers

PMID: 1990060
DOI: 10.1099/0022-1317-72-1-125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1990060-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Comparison of the virulence of wild-type thymidine kinase (tk)-deficient and tk+ phenotypes of vaccinia virus recombinants after intranasal inoculation of mice.PMID 1990060Read ↗

Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype.Semantic proximity Read ↗

Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2.Semantic proximity Read ↗

Insertional inactivation of the large subunit of ribonucleotide reductase encoded by vaccinia virus is associated with reduced virulence in vivo.Semantic proximity Read ↗

Pathogenicity of a thymidine kinase-deficient mutant of equine herpesvirus 1 in mice and specific pathogen-free foals.Semantic proximity Read ↗

Recombinant measles viruses with mutations in the C, V, or F gene have altered growth phenotypes in vivo.Semantic proximity Read ↗

Specific phenotypic restoration of an attenuated virus by knockout of a host resistance geneSemantic proximity Read ↗

Deletion of the Herpes simplex 1 internal repeat sequences affects pathogenicity in the mouse.Semantic proximity Read ↗

Complementary lethal invasion of the central nervous system by nonneuroinvasive herpes simplex virus types 1 and 2.Semantic proximity Read ↗

[Attenuation in the virulence of a mutant of Junin virus in suckling mice].Semantic proximity Read ↗

Immediate protection of mice from lethal wild-type Sendai virus (HVJ) infections by a temperature-sensitive mutant, HVJpi, possessing homologous interfering capacity.Semantic proximity Read ↗

Experimental infection of suckling mice with a host range mutant of Junin virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.