Article
Linkage analysis by two-dimensional DNA typing.
American journal of human genetics - 1 Dec 1993
te Meerman G J, Mullaart E, van der Meulen M A, den Daas J H, Morolli B, Uitterlinden A G, Vijg J
Abstract excerpt
In two-dimensional (2-D) DNA typing, genomic DNA fragments are separated, first according to size by electrophoresis in a neutral polyacrylamide gel and second according to sequence by denaturing gradient gel electrophoresis, followed by hybridization analysis using micro- and minisatellite core probes. The 2-D DNA typing method generates a large amount of information on polymorphic loci per gel. Here we...
Topics
- Alleles
- Animals
- Cattle
- Chromosome Mapping
- Computer Simulation
- DNA
- DNA Probes
- DNA, Satellite
- Electrophoresis, Polyacrylamide Gel
- Female
- Gene Frequency
- Genetic Linkage