Article
Toward fully automated genotyping: genotyping microsatellite markers by deconvolution.
American journal of human genetics - 1 Nov 1995
Perlin M W, Lancia G, Ng S K
Abstract excerpt
Dense genetic linkage maps have been constructed for the human and mouse genomes, with average densities of 2.9 cM and 0.35 cM, respectively. These genetic maps are crucial for mapping both Mendelian and complex traits and are useful in clinical genetic diagnosis. Current maps are largely comprised of abundant, easily assayed, and highly polymorphic PCR-based microsatellite markers, primarily dinucleotide (CA)n...
Topics
- Algorithms
- Animals
- DNA, Satellite
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans
- Mice
- Models, Genetic
- Polymerase Chain Reaction