Article
High-density genotyping and linkage disequilibrium in the human genome using chromosome 22 as a model.
Current opinion in chemical biology - 1 Feb 2002
Remm Maido, Metspalu Andres
Abstract excerpt
Technology and genetics have advanced to the point where genotyping thousands of individuals at thousands of marker locations around the whole human genome is possible. The whole-genome scan for detection of complex disease genes is a widely discussed topic. We review some of the recent high-density genotyping experiments and discuss related details, particularly the extent and variability of linkage...
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