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Article

Selective loss of imprinting in the placenta following preimplantation development in culture.

Development (Cambridge, England) - 1 Aug 2004

Mann Mellissa R W, Lee Susan S, Doherty Adam S, Verona Raluca I, Nolen Leisha D, Schultz Richard M, Bartolomei Marisa S

Abstract excerpt

Preimplantation development is a period of dynamic epigenetic change that begins with remodeling of egg and sperm genomes, and ends with implantation. During this time, parental-specific imprinting marks are maintained to direct appropriate imprinted gene expression. We previously demonstrated that H19 imprinting could be lost during preimplantation development under certain culture conditions. To define the...

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PMID: 15240554
DOI: 10.1242/dev.01241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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