Article
Introduction of a DNA methyltransferase into Drosophila to probe chromatin structure in vivo.
Chromosoma - 1 Jan 1996
Wines D R, Talbert P B, Clark D V, Henikoff S
Abstract excerpt
The dam DNA methyltransferase gene from Escherichia coli was introduced into Drosophila in order to probe chromatin structure in vivo. Expression of the gene caused no visible defects or developmental delay even at high levels of active methylase. About half of each target site was found to be methylated in vivo, apparently reflecting a general property of chromatin packaged in nucleosomes. Although site-specific...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.