Article
Position effect variegation and chromatin proteins.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Sept 1992
Reuter G, Spierer P
Abstract excerpt
Variegated phenotypes often result from chromosomal rearrangements that place euchromatic genes next to heterochromatin. In such rearrangements, the condensed structure of heterochromatin can spread into euchromatic regions, which then assume the morphology of heterochromatin and become transcriptionally inactive. In position-effect variegation (PEV) therefore, gene inactivation results from a change in chromatin...
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