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Article

Long-range nucleosome ordering is associated with gene silencing in Drosophila melanogaster pericentric heterochromatin.

Molecular and cellular biology - 1 Apr 2001

Sun F L, Cuaycong M H, Elgin S C

Abstract excerpt

We have used line HS-2 of Drosophila melanogaster, carrying a silenced transgene in the pericentric heterochromatin, to investigate in detail the chromatin structure imposed by this environment. Digestion of the chromatin with micrococcal nuclease (MNase) shows a nucleosome array with extensive long-range order, indicating regular spacing, and with well-defined MNase cleavage fragments, indicating a smaller MNase...

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Identifiers

PMID: 11283265
DOI: 10.1128/MCB.21.8.2867-2879.2001
PMCID: PMC86916

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