Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RET activation by germline MEN2A and MEN2B mutations.

Oncogene - 7 Dec 1995

Borrello M G, Smith D P, Pasini B, Bongarzone I, Greco A, Lorenzo M J, Arighi E, Miranda C, Eng C, Alberti L

Abstract excerpt

The RET proto-oncogene encodes a receptor tyrosine kinase (TK). It has been shown that distinct germline mutations in the RET proto-oncogene are associated with the dominantly inherited cancer syndromes multiple endocrine neoplasia type 2A and 2B (MEN 2A and MEN 2B) and familial medullary thyroid carcinoma (FMTC) as well as Hirschsprung disease (HSCR), a congenital disorder characterised by absent enteric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phenotype
Share to Phosphorylation
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Molecular Sequence Data

Share to Oligodeoxyribonucleotides

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 8570194

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RET activation by germline MEN2A and MEN2B mutations.PMID 8570194Read ↗

Molecular Mechanisms of RET Activation in Human CancerSemantic proximity Read ↗

Cellular mechanisms of RET receptor dysfunction in multiple endocrine neoplasia 2.Semantic proximity Read ↗

RET tyrosine kinase signaling in development and cancer.Semantic proximity Read ↗

Molecular mechanisms of development of multiple endocrine neoplasia 2 by RET mutations.Semantic proximity Read ↗

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B.Semantic proximity Read ↗

Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis.Semantic proximity Read ↗

Molecular implications of RET mutations for pheochromocytoma risk in multiple endocrine neoplasia 2.Semantic proximity Read ↗

Full activation of MEN2B mutant RET by an additional MEN2A mutation or by ligand GDNF stimulation.Semantic proximity Read ↗

Mechanisms of development of multiple endocrine neoplasia type 2 and Hirschsprung's disease by ret mutations.Semantic proximity Read ↗

RET and neuroendocrine tumors.Semantic proximity Read ↗

RET oncogene in MEN2, MEN2B, MTC and other forms of thyroid cancer.Semantic proximity Read ↗

Multiple endocrine neoplasia syndromes, children, Hirschsprung's disease and RET.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.