RET activation by germline MEN2A and MEN2B mutations.

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Article

RET activation by germline MEN2A and MEN2B mutations.

Oncogene - 7 Dec 1995

Borrello M G, Smith D P, Pasini B, Bongarzone I, Greco A, Lorenzo M J, Arighi E, Miranda C, Eng C, Alberti L

Abstract excerpt

The RET proto-oncogene encodes a receptor tyrosine kinase (TK). It has been shown that distinct germline mutations in the RET proto-oncogene are associated with the dominantly inherited cancer syndromes multiple endocrine neoplasia type 2A and 2B (MEN 2A and MEN 2B) and familial medullary thyroid...

Topics

3T3 Cells
Animals
Base Sequence
Drosophila Proteins
Germ-Line Mutation
Hirschsprung Disease
Humans
Mice
Molecular Sequence Data
Multiple Endocrine Neoplasia
Multiple Endocrine Neoplasia Type 2a
Multiple Endocrine Neoplasia Type 2b

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Phenotype

Phosphorylation

Proto-Oncogene Mas

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-ret

Source

Open in PubMed

Identifiers

PMID: 8570194

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8570194-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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