Article
Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B.
Science (New York, N.Y.) - 20 Jan 1995
Santoro M, Carlomagno F, Romano A, Bottaro D P, Dathan N A, Grieco M, Fusco A, Vecchio G, Matoskova B, Kraus M H
Abstract excerpt
Multiple endocrine neoplasia types 2A and 2B (MEN2A and MEN2B) and familial medullary thyroid carcinoma are dominantly inherited cancer syndromes. All three syndromes are associated with mutations in RET, which encodes a receptor-like tyrosine kinase. The altered RET alleles were shown to be tran...
Topics
- 3T3 Cells
- Alleles
- Animals
- Cell Transformation, Neoplastic
- Drosophila Proteins
- Genetic Vectors
- Humans
- Mice
- Multiple Endocrine Neoplasia Type 2a
- Multiple Endocrine Neoplasia Type 2b
- Mutation
- Phosphorylation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-ret