Article
Full activation of MEN2B mutant RET by an additional MEN2A mutation or by ligand GDNF stimulation.
Oncogene - 7 May 1998
Bongarzone I, Vigano E, Alberti L, Borrello M G, Pasini B, Greco A, Mondellini P, Smith D P, Ponder B A, Romeo G, Pierotti M A
Abstract excerpt
Germline mutations of RET gene, encoding a receptor tyrosine kinase, have been associated with the MEN2A and MEN2B inherited cancer syndromes. In MEN2A mutations affecting cysteine residues in the extracellular domain of the receptor cause constitutive activation of the tyrosine kinase by the formation of disulfide-bonded homodimers. In MEN2B a single mutation in the tyrosine kinase domain (Met918Thr) has been...
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