Article
Association between schizophrenia and genetic variation in DCC: a case-control study.
Schizophrenia research - 1 May 2012
Grant Alanna, Fathalli Ferid, Rouleau Guy, Joober Ridha, Flores Cecilia
Abstract excerpt
Schizophrenia is a highly heritable neurodevelopmental disorder associated with alterations in synaptic connectivity. Deleted in colorectal cancer (DCC), a receptor for the guidance cue netrin-1, plays a pivotal role in organizing neuronal circuitry by guiding growing axons and dendrites to their correct targets and by influencing synaptic connectivity. Results from experiments we previously conducted in...
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