Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple sclerosis in sibling pairs: an analysis of 250 families.

Journal of neurology, neurosurgery, and psychiatry - 1 Dec 2001

Chataway J, Mander A, Robertson N, Sawcer S, Deans J, Fraser M, Broadley S, Clayton D, Compston A

Abstract excerpt

OBJECTIVES: To assess the potential contribution of genetic factors to clinical phenotype in multiple sclerosis. METHODS: Using a cohort of 262 pairs of coaffected siblings from 250 families with multiple sclerosis, intersibling concordance analysis was used to explore underlying genetic mechanisms in disease pathogenesis by assessing parameters of disease course, clinical presentation, age and year of onset, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to United Kingdom
Share to Activities of Daily Living

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Analysis of Variance

Share to Confounding Factors, Epidemiologic

Share to Multiple Sclerosis, Chronic Progressive

Share to Multiple Sclerosis, Relapsing-Remitting

Share to Persons with Disabilities

Share to Registries

Source

Open in PubMed Open full text

Identifiers

PMID: 11723196
DOI: 10.1136/jnnp.71.6.757
PMCID: PMC1737661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple sclerosis in sibling pairs: an analysis of 250 families.PMID 11723196Read ↗

Concordance for disease course and age of onset in Scandinavian multiple sclerosis coaffected sib pairs.Semantic proximity Read ↗

Familial effects on the clinical course of multiple sclerosis.Semantic proximity Read ↗

Age of onset in concordant twins and other relative pairs with multiple sclerosis.Semantic proximity Read ↗

Genetic basis for clinical expression in multiple sclerosis.Semantic proximity Read ↗

A population‐based study of multiple sclerosis in twins: UpdateSemantic proximity Read ↗

Concordance and heritability of multiple sclerosis in Finland: study on a nationwide series of twins.Semantic proximity Read ↗

Evaluation of clinical concordance in FMF siblings with identical biallelic exon 10 variants.Semantic proximity Read ↗

Clinicopathological concordance and discordance in three monozygotic twin pairs with familial Alzheimer's disease.Semantic proximity Read ↗

Concordance for multiple sclerosis in Danish twins: an update of a nationwide study.Semantic proximity Read ↗

Multiple sclerosis in 54 twinships: Concordance rate is independent of zygositySemantic proximity Read ↗

Twin concordance and sibling recurrence rates in multiple sclerosis.Semantic proximity Read ↗

Parent-of-origin effects in MSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.