Article
Evidence that allelic variants of the spinocerebellar ataxia type 2 gene influence susceptibility to multiple sclerosis.
Neurogenetics - 1 Apr 1999
Chataway J, Sawcer S, Coraddu F, Feakes R, Broadley S, Jones H B, Clayton D, Gray J, Goodfellow P N, Compston A
Abstract excerpt
Expanded CAG trinucleotide repeats are known to be responsible for five of the autosomal dominant spinocerebellar ataxias (SCA1, SCA2, SCA3, SCA6, and SCA7). We have typed each of these repeats in 226 multiple sclerosis sibling pair families. No expanded repeats were seen, indicating an absence of SCA phenocopies in clinically defined familial multiple sclerosis. However, transmission disequilibrium testing for...
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