Article
Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus.
The Journal of clinical investigation - 15 Feb 1997
Tsao B P, Cantor R M, Kalunian K C, Chen C J, Badsha H, Singh R, Wallace D J, Kitridou R C, Chen S L, Shen N, Song Y W, Isenberg D A, Yu C L, Hahn B H, Rotter J I
Abstract excerpt
Genetic susceptibility confers significant risk for systemic lupus erythematosus (SLE). The MHC region and other polymorphic loci have been associated with SLE. Because more compelling evidence for an involvement of a genetic locus includes linkage, we tested a candidate region homologous to a murine SLE susceptibility region in 52 SLE-affected sibpairs from three ethnic groups. We analyzed seven microsatellite...
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