Article
Multiple sclerosis susceptibility and the X chromosome.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Aug 2007
Herrera B M, Cader M Z, Dyment D A, Bell J T, Deluca G C, Willer C J, Lincoln M R, Ramagopalan S V, Chao M, Orton S-M, Sadovnick A D, Ebers G C
Abstract excerpt
Multiple sclerosis (MS) is a chronic autoimmune complex trait with strong evidence for a genetic component. A female gender bias is clear but unexplained and a maternal parent-of-origin effect has been described. X-linked transmission of susceptibility has been previously proposed, based on pedigree, association and linkage studies. We genotyped 726 relative pairs including 552 affected sib-pairs for 22...
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