Article
Follow-up investigation of 12 proposed linkage regions in multiple sclerosis.
Genes and immunity - 1 Jul 2006
Herrera B M, Cader M Z, Dyment D A, Bell J T, Ramagopalan S V, Lincoln M R, Orton S, Chao M J, Sadovnick A D, Ebers G C
Abstract excerpt
Multiple sclerosis (MS) is an autoimmune disease with overwhelming evidence for genetic determination, and for which a maternal parent-of-origin effect has been reported. As with many complex diseases, multiple suggestive linkage signals have been observed. However, the only unambiguous association and linkage identified to date is with alleles of the human lymphocyte antigen (HLA) class II region. We have now...
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