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Article

A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis.

Nature genetics - 1 Oct 2005

Lincoln Matthew R, Montpetit Alexandre, Cader M Zameel, Saarela Janna, Dyment David A, Tiislar Milvi, Ferretti Vincent, Tienari Pentti J, Sadovnick A Dessa, Peltonen Leena, Ebers George C, Hudson Thomas J

Abstract excerpt

Genetic susceptibility to multiple sclerosis is associated with genes of the major histocompatibility complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref. 1). Both locus and allelic heterogeneity have been reported in this genomic region. To clarify whether HLA-DRB1 itself, nearby genes in the region encoding the MHC or combinations of these loci underlie susceptibility to multiple sclerosis, we genotyped...

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PMID: 16186814
DOI: 10.1038/ng1647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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