Article
DR2/DQw1 inheritance and haplotype sharing in affected siblings from multiple sclerosis families.
Annals of neurology - 1 Jun 1996
Voskuhl R R, Goldstein A M, Simonis T, Davey R J, McFarland H F
Abstract excerpt
Although the human leukocyte antigen DR2/DQw1 allele has been associated with multiple sclerosis, studies of DR2/DQw1 inheritance in multiple sclerosis multiplex families have yielded conflicting results. We examined this question in "high-incidence" families, defined as families with more than 50% of siblings affected. DR2/DQw1 allele frequencies were significantly increased, particularly in mothers and affected...
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