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Article

Interfering with Apoptosis: Ca <sup>2+</sup> -Binding Protein ALG-2 and Alzheimer's Disease Gene <i>ALG-3</i>

26 Jan 1996

Abstract excerpt

Two apoptosis-linked genes, named ALG-2 and ALG-3, were identified by means of a functional selection strategy. ALG-2 codes for a Ca(2+)-binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3, a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2, rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These...

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PMID: 8560270
DOI: 10.1126/science.271.5248.521

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Interfering with Apoptosis: Ca <sup>2+</sup> -Binding Protein ALG-2 and Alzheimer's Disease Gene <i>ALG-3</i>PMID 8560270Read ↗

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