Article
G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.
The EMBO journal - 15 Aug 1997
Giambarella U, Yamatsuji T, Okamoto T, Matsui T, Ikezu T, Murayama Y, Levine M A, Katz A, Gautam N, Nishimoto I
Abstract excerpt
In familial Alzheimer's disease (FAD), three missense mutations, V642I, V642F and V642G, that co-segregate with the disease phenotype have been discovered in the 695 amino acid form of the amyloid precursor protein APP. Expression of these mutants causes a COS cell NK1 clone to undergo pertussis...
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