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Article

Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein.

Cell death and differentiation - 1 Feb 1999

Missotten M, Nichols A, Rieger K, Sadoul R

Abstract excerpt

ALG-2 is a EF hand calcium binding protein with sequence homologies to calmodulin. Vito et al have shown that ALG-2 expression is required for apoptosis following a number of death stimuli,1 although nothing is known about the effectors which underlie ALG-2 function. Here we have used ALG-2 as bait in a yeast two hybrid screen of a mouse brain cDNA library. We found that ALG-2 binds to itself and to a novel...

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Source

Identifiers

PMID: 10200558
DOI: 10.1038/sj.cdd.4400456

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein.PMID 10200558Read ↗

Two forms of the apoptosis-linked protein ALG-2 with different Ca(2+) affinities and target recognition.Semantic proximity Read ↗

Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.Semantic proximity Read ↗

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A microtubule-associated protein MAP1B binds to and regulates localization of a calcium-binding protein ALG-2.Semantic proximity Read ↗

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Mapping of the interaction sites between apoptosis linked gene ALG-2 and HEED.Semantic proximity Read ↗

ALG-2 oscillates in subcellular localization, unitemporally with calcium oscillations.Semantic proximity Read ↗

The apoptosis linked gene ALG‐2 is dysregulated in tumors of various origin and contributes to cancer cell viabilitySemantic proximity Read ↗

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