Article
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease.
Science (New York, N.Y.) - 18 Jul 1997
Kim T W, Pettingell W H, Jung Y K, Kovacs D M, Tanzi R E
Abstract excerpt
Most cases of early-onset familial Alzheimer's disease (FAD) are caused by mutations in the genes encoding the presenilin 1 (PS1) and PS2 proteins, both of which undergo regulated endoproteolytic processing. During apoptosis, PS1 and PS2 were shown to be cleaved at sites distal to their normal cleavage sites by a caspase-3 family protease. In cells expressing PS2 containing the asparagine-141 FAD mutant, the...
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