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Article

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype.

The EMBO journal - 1 Feb 1996

Yamatsuji T, Okamoto T, Takeda S, Murayama Y, Tanaka N, Nishimoto I

Abstract excerpt

APP is a transmembrane precursor of beta-amyloid. In dominantly inherited familial Alzheimer's disease (FAD), point mutations V6421, V642F and V642G have been discovered in APP695. Here we show that expression of these mutants (FAD-APPs) causes a clone of COS cells to undergo apoptosis associated with DNA fragmentation. Apoptosis by the three FAD-APPs was the highest among all possible V642 mutants; normal APP695...

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Identifiers

PMID: 8599933
PMCID: PMC449968

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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