Article
A high-throughput screen for single gene activities: isolation of apoptosis inducers.
Biochemical and biophysical research communications - 16 May 2003
Albayrak Timur, Grimm Stefan
Abstract excerpt
We describe a novel genetic screen that is performed by transfecting every individual clone of an expression library into a separate population of cells in a high-throughput mode. The screen allows one to achieve a hitherto unattained sensitivity in expression cloning which was exploited in a first read-out to clone apoptosis-inducing genes. This led to the isolation of several genes whose proteins induce...
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