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Article

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

Science (New York, N.Y.) - 9 Feb 1996

Joneson T, White M A, Wigler M H, Bar-Sagi D

Abstract excerpt

The RAS guanine nucleotide binding proteins activate multiple signaling events that regulate cell growth and differentiation. In quiescent fibroblasts, ectopic expression of activated H-RAS (H-RASV12, where V12 indicates valine-12) induces membrane ruffling, mitogen-activated protein (MAP) kinase activation, and stimulation of DNA synthesis. A mutant of activated H-RAS, H-RASV12C40 (where C40 indicates...

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PMID: 8628998
DOI: 10.1126/science.271.5250.810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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