Article
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.
Science (New York, N.Y.) - 9 Feb 1996
Joneson T, White M A, Wigler M H, Bar-Sagi D
Abstract excerpt
The RAS guanine nucleotide binding proteins activate multiple signaling events that regulate cell growth and differentiation. In quiescent fibroblasts, ectopic expression of activated H-RAS (H-RASV12, where V12 indicates valine-12) induces membrane ruffling, mitogen-activated protein (MAP) kinase...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Division
- Cell Line
- Cell Membrane
- DNA
- Enzyme Activation
- GTP-Binding Proteins
- Microinjections
- Mutation
- Plasmids
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-raf
- Rats
- Signal Transduction
- rac GTP-Binding Proteins
- ras Proteins