Both Sm and DNA are selecting antigens in the anti-Sm B cell response in autoimmune MRL/lpr mice.

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Article

Both Sm and DNA are selecting antigens in the anti-Sm B cell response in autoimmune MRL/lpr mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1996

Retter M W, Cohen P L, Eisenberg R A, Clarke S H

Abstract excerpt

More than half of the anti-Sm hybridomas isolated from MRL/Mp-lpr/lpr (MRL/lpr) mice produce Abs that also bind ssDNA, and half of these bind dsDNA. Intraclonal comparisons indicate that DNA is a selecting Ag for at least some dual-binding clones. To determine whether Sm itself is a selecting Ag for anti-Sm, we have identified the somatic mutations within the expressed VH and V kappa genes of eight anti-Sm...

Topics

Amino Acid Sequence
Animals
Autoantibodies
Autoantigens
Autoimmune Diseases
Base Sequence
DNA
DNA, Single-Stranded
Genes, Immunoglobulin
Hybridomas
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Mutant Strains

Molecular Sequence Data

Mutation

Ribonucleoproteins, Small Nuclear

snRNP Core Proteins

Source

Open in PubMed

Identifiers

PMID: 8558010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8558010-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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