Article
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.
The Journal of experimental medicine - 1 Jan 1990
Shlomchik M, Mascelli M, Shan H, Radic M Z, Pisetsky D, Marshak-Rothstein A, Weigert M
Abstract excerpt
The proximate cause of autoantibodies characteristic of systemic autoimmune diseases has been controversial. One hypothesis is that autoantibodies are the result of polyclonal nonspecific B cell activation. Alternatively, autoantibodies could be the result of antigen-driven B cell activation, as...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- Autoantibodies
- Autoimmune Diseases
- Base Sequence
- Clone Cells
- DNA
- DNA, Single-Stranded
- Enzyme-Linked Immunosorbent Assay
- Genes, Immunoglobulin
- Immunoglobulin Heavy Chains
- Immunoglobulin Joining Region