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Article

DNA-binding antibodies from viable motheaten mutant mice: implications for B cell tolerance.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1997

Westhoff C M, Whittier A, Kathol S, McHugh J, Zajicek C, Shultz L D, Wylie D E

Abstract excerpt

C57BL/6 me(v)/me(v) (viable motheaten) mice have defective hemopoietic cell protein-tyrosine phosphatase (HCP, SHP-1) and are a model in which to study the role of this phosphatase in immune regulation and hemopoietic development. Immune defects in these mice include hypergammaglobulinemia, production of multiple autoantibodies, and glomerular nephritis. The presence of self-reactive Abs in these mice is an...

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PMID: 9300728

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