Article
Independently derived IgG anti-DNA autoantibodies from two lupus-prone mouse strains express a VH gene that is not present in most murine strains.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1993
Gangemi R M, Singh A K, Barrett K J
Abstract excerpt
The origin and structure of two clonally unrelated IgG anti-DNA autoantibodies from lupus-prone MRL/Ipr mice were examined. One of these antibodies, H241, binds dsDNA and glomeruli and deposits in the kidneys of normal mice, whereas the other, H102, binds only ssDNA and does not deposit in kidney...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Antinuclear
- Base Sequence
- Cell Line
- DNA
- Genes, Immunoglobulin
- Immunoglobulin G
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Lupus Erythematosus, Systemic
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutation