Article
The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies.
Clinical immunology and immunopathology - 1 Jul 1995
Gilkeson G S, Bernstein K, Pippen A M, Clarke S H, Marion T, Pisetsky D S, Ruiz P, Lefkowith J B
Abstract excerpt
Antibodies to DNA (anti-DNA) occur prominently in systemic lupus erythematosus and provoke inflammatory damage in the kidneys. To determine the factors that confer pathogenicity on antibodies of this specificity, we investigated the in vitro and in vivo glomerular binding by members of four clonally related sets of monoclonal anti-DNA antibodies from lupus mice. Somatic mutations within the clonal sets enhanced...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Antinuclear
- Antibodies, Monoclonal
- Antibody Specificity
- DNA
- Female
- Hybridomas
- Immunoglobulin Variable Region
- Kidney Glomerulus